Impaired noradrenaline response to glucose ingestion in NIDDM.
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概要
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Noradrenaline (NA) levels in the circulation is considered to reflect sympathetic nervous activity in humans. This study was conducted to clarify the NA response to glucose ingestion (75 g) in ten non-insulin-dependent diabetic inpatients (NIDDM) and eight inpatients with normal glucose tolerance free from autonomic disturbances (controls).<BR>Venous blood samples were withdrawn at 30-min intervals for 2 h and at 60-min interval for 1 h to determine plasma glucose, serum NEFA, IRI, CPR, potassium, NA and adrenaline levels. The following results were obtained:<BR>1) In the controls, the maximum increase in serum NA levels occurred at 30 min after glucose ingestion, but in the diabetics, the mean serum NA levels remained unchanged.<BR>The effects of glucose ingestion were significantly different between diabetics and controls according to the analysis of variance for serum NA levels (p<0.05).<BR>2) In the total group (n=18), positive correlations were found between 4 NA 30 min and ΔIRI 30min (r=0.52, P<0.05), between %ΔNA 30min and ΔIRI 30min (r=0.56, P<0.05), bctween ΔNA 30min and ΔIRI/Δ Glucose ratio (insulinogcnic index)(r=0.70, P<0.01), and between %ΔNA 30min and ΔIRI/ΔGlucose ratio (r=0.69, p<0.01).<BR>3) In four diabetics, NA responses to glucose ingestion were studied again after caloric restriction for 2 weeks. In three of them, both the NA response and the IRI response to glucose ingestion were improved after diet therapy, but in the remainder, the NA response to glucose ingestion remained unchanged in accordance with the sustained poor insulin response to glucose ingestion.<BR>In conclusion, it appears that the NA response to glucose ingestion is regulated primarily by the insulin response to glucose ingestion, and the impairment of the NA response to glucose ingestion constitutes one of the etiologic factors for the development of autonomic disturbances or metabolic derangement in NIDDM.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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