The adoptive transfer of spleen cells from Cyclosporin-treated NOD mice inhibits the development of insulitis in young NOD mice.
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The adoptive transfer of spleen cells from Cyclosporin-treated NOD mice was performed to investigate the involvement of suppressor T cells in the preventive effect of Cyclosporin on insulitis in NOD mice.<BR>The donor spleen cells were obtained from female NOD mice with acute diabetes (Group I), Group I + Cyclosporin-treated (25 mg / kg/2 days for 40 days) female NOD mice aged 100 days (Group II), Group I + Cyclosporin-treated (25 mg/kg/2 days for 40 days) female NOD mice aged over 240 days (Group III), and female NOD mice aged 30 days (Group IV). The recipients of all groups were female NOD mice aged 30 days. Plasma glucose was measured every week, and 4 weeks after the transfer the pancreases were examined for histological changes. There was no significant difference in the plasma glucose levels in any group throughout the experiment. When the intensity of insulitis was graded 0 to 3, the intensity of insulitis in Groups I and III was reinforced significantly more than that in Group IV and the development of insulitis in Group II was more significantly suppressed than that in Group I.<BR>1) The adoptive transfer of spleen cells from old NOD mice with acute diabetes accelerated the development of insulitis in young NOD mice, without inducing hyperglycemia. 2) The additional adoptive transfer of spleen cells from Cyclosporin-treated NOD mice decreased the acceleration of development of insulitis observed in young NOD mice which received spleen cells alone from old NOD mice with acute diabetes. 3) This effect was not demonstrated in the experiments where Cyclopsporin-treated mice aged over 240 days were used as donor.<BR>These results indicate that active suppressor mechanisms are involved in the preventive effect of Cyclosporin on insulitis in NOD mice.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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