Changes in blood glucose after embolization of the hepatic artery.

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Recently, embolization of the hepatic artery has been widely used as a therapy for hepatoma. However, hyperglycemia experienced after such embolization has not been reported. In this study nineteen cases of hepatoma and fourteen cases of liver cirrhosis (group C) were studied. In nine (group A) out of the nineteen hepatoma cases, embolization was performed, while in the remaining ten (group B) hepatoma cases, this procedure was not done. Changes in blood glucose before and after hepatic artery embolization were investigated retrospectively. The increases in blood glucose were 52.9±17.2 mg/dl (mean±SEM), 4±4.4mg/dl, and-0.9±4.1mg/dl in groups A, B and C, respectively. In the nineteen subjects with hepatoma and the fourteen cases with liver cirrhosis, multivariate regression analysis was performed using the change in glucose as an objective variable and ICG, the degree of embolization, tumor size, and the use of steroid hormones as explaining variables. An equation (change in glucose=-20.7+0.76×ICG+25.2×the degree of embolization) was cbtained. The equation explained the change of glucose in an external sample very well. This indicated that the glucose change induced was mainly affected by the value of ICG and the degree of embolization. This suggested that the hepatic reserve and the hepatic injury caused by the blockage of the artery explained the glucose change.
一般社団法人日本糖尿病学会の論文