Complement and ICSA in IDDM in childhood.
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概要
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The purpose of the present study was to examine the relation between ICSA, which is detected early in the course of IDDM in childhood, and the complement system. From among 90 children with IDDM occurring before 15 years of age who participated in summer diabetes camps in two populous districts of western Japan, 21 patients whose onsets of the disease were less than one year prior to the camps were chosen for study. ICSA was detected by the original method of Lernmark. C3 and C4 blood levels were determined by the immunodiffusion technique. Student's t-test was used for statistical analysis of the data.<BR>Of the 21 patients 11 were ICSA-positive and the remaining 10 were negative for ICSA. The ICSA-positive patients had a mean blood C3 level of 63.6±8.9mg/d<I>l</I> (SD) which was lower than that of the ICSA-negative patients (76.6±13.3mg/d<I>l</I>)(p<0.02). The mean C4 blood level of the ICSA-positive patients (20.5±5.3 mg/d<I>l</I>) was lower than that of the ICSA-negative patients (31.8±9.0mg/d<I>l</I>)(p<0.01). These findings suggest the possibility that complement-dependent antibodymediated cytotoxicity may play a role in the pathogenesis of IDDM in childhood.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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