Mortality and causes of death among Japanese diabetics: Factors present at entry influencing the prognosis - A prospective five-year follow-up study.:A Prospective Five-year Follow-up Study
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To elucidate the prognosis of diabetic patients in Japan, we undertook a prospective follow-up study of 1, 629 diabetic patients (898 males, 731 females) who visited our Diabetes Center in 1976. In this paper, we describe the results of a five-year follow-up study, especially regarding the relationship between factors present at entry and the prognosis of diabetics.<BR>During this follow-up study, only three cases dropped out within five years from the start. The deaths of 184 (127 males, 57 females) were confirmed at the end of the five-year follow-up. We obtained copies of death certificates for all the deceased patients.<BR>Unfavorable prognostic factors at entry were as follows: an age at onset of younger than 30 years, a relative body weight of less than 90%, insulin treatment, a systolic blood pressure in excess of 200 mm Hg, a diastolic blood pressure in excess of 110mm Hg, a fasting plasma glucose level of more than 200 mg/d<I>l</I>, a plasma total cholesterol level of less than 150mg/d<I>l</I> or more than 300 mg/d<I>l</I>, a plasma triglyceride level of more than 300 mg/d<I>l</I>, a plasma urea nitrogen level of more than 30 mg/d<I>l</I>, a plasma uric acid level of more than 10 mg/dl, and the presence of diabetic neuropathy, retinopathy or proteinuria.<BR>Malignant neoplasms were the leading cause of deatd among all the deceased diabetics and cerebrovascular disease, ischemic heart disease diabetic nephropathy and infections followed, in that order. However, diabetic nephropathy, ischemic heart disease and cerebrovascular disease were the main causes of death among the cases with following factors at entry; an age at onset of younger than 30 years, a relative body weight of more than 130%, a systolic blood pressure of more than 180mm Hg, a diastolic blood pressure of more than 100 mm Hg, a plasma total cholestcrol level of more than 300mg/d<I>l</I>, a plasma triglyceride level of more than 300mg/d<I>l</I>, a plasma urea nitrogen level of more than 30 mg/d<I>l</I>, a plasma uric acid level of more than 10mg/d<I>l</I>, and the presence of diabetic neuropathy, proliferative retinopathy or proteinuria.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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