Studies on HLA in Japanese Diabetics with Juvenile Onset Eid Insulin-Dependency (JOD) with Special Reference to a Family History of Diabetes Mellitus
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概要
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Twenty-nine unrelated Japanese patients with insulin dependent diabetes mellitus with juvenileonset (JOD) were HLA typed with special reference to family history.<BR>The following results were obtained.<BR>1) The frequency of BJW 22-2, a Japanese specific subclass of BW 22, was significantly (x<SUP>2</SUP>y= 20.7) increased in JOD, as a whole, compared with the control group.<BR>2) The frequency of B 5 was significantly (x<SUP>2</SUP>=16.4) decreased in JOD as a whole.<BR>3) Of twenty-nine JOD patients, twelve had a family history of maturity-onset diabetes (MOD), and seventeen had no apparent family history of diabetes mellitus. Among JOD patients with a positive family history of MOD, two with an insidious onset and one with a history of obesity before the onset were found. The incidence of ketonuria and emaciation was less frequent in this group than in the group without a positive family history of MOD.<BR>4) In the group with a positive family history no difference in phenotype frequencies of HLA was found when compared with a control.<BR>5) In the group without a family history, the frequency of BJW 22-2 was significantly (x<SUP>2</SUP>=19.7) increased and no patient had B 5. The frequency of a positive response in the leucocyte migration inhibition test, using mitochondrial fraction of islet cell as an antigen, was significantly higher in this group than in the group with a family history.<BR>These results suggest a genetical as well as clinical heterogeneity of so-called JOD.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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