Glucose Tolerance and Insulin Secretion in Patients with Periodic Paralysis.
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To evaluate the glucose tolerance and insulin secretion, intravenous high-dose glucose load and oral glucose tolerance test (GTT) were performed in patients with thyrotoxic and idiopathic periodic paralysis.<BR>Blood sugar, serum insulin, and serum electrolytes were determined in twelve male patients with thyrotoxic periodic paralysis and in three male patients with idiopathic periodic paralysis who were subjected to intravenous infusion of 500 ml of 50% glucose solution in 60 minutes and to oral GTT.<BR>Blood sugar levels on intravenous high-dose glucose load and on oral GTT were remarkably increased in the two patient groups compared with the results in normal subjects.<BR>Serum insulin levels on intravenous high-dose glucose load were significantly lower in both patient groups than in the control. A significant increase in the insulin levels on oral GTT was observed in the female group with hyperthyroidism in comparison with the male group of hyperthyroidism, idiopathic periodic paralysis group and normal subjects. Serum insulin levels in patients mith thyrotoxic periodic paralysis were similar to those in the female group with hyperthyroidism. The values of ΔIRI/ΔBS (30 minutes) in patients with idiopathic periodic paralysis were lower than those in normal subjects and the female group with hyperthyroidism.<BR>It may be concluded that there is decreased glucose tolerance in patients with thyrotoxic and idiopathic periodic paralysis, and decreased insulin secretion in patients with idiopathic periodic paralysis. Insulin secretions in patient with thyrotoxic periodic paralysis has a significantly low response to intravenous high-dose glucose load, and very high response to oral GTT.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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