Clinical Effects of Glipizide in Maturity-onset Diabetic Patients:Evaluation by Double Blind Test
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The blood sugar controlling effects and the side effects of Glipizide were compared with those of Tolbutamide, used as a control drug, in 243 cases from 9 institutions by means of a double blind test. Based on analyses of the homogeneity of the cases differences were revealed in the constituents of both groups. Factors which were considered to alfer the effects of the drugs were also examined after classification of the patients, together with an overall analysis. In the overall examination of the drug effects, no significant differences were found between the groups in (1) global judgment, (2) number of weeks showing the excellent or good control of blood sugar during the observation period from the 4th to the 12th week, or (3) number of weeks needed from initiation of the treatment to the obtaining of good control. In the analysis of drug effects after classifying the duration of diabetes into three groups (less than 6 months, 6 months to less than 3 years, and more than 3 years), significant differences were observed at the 5% level between the two drugs in the group of 6 months to less than 3 years: Glipizide was shown to have a better blood sugar controlling effect than Tolbutamide.<BR>No differences were observed between the drugs in changes in subjective or objective symptoms which were considered to be related to drug effects, but there was a tendency for symptoms to be less improved in already treated patients than in untreated ones. No differences were found in side effects between the groups, and no special side effects were seen other than those generally encountered in treatment with sulfonylureas. Hypoglycemic symptoms were observed slightly more frequently in the Glipizide group.<BR>Laboratory tests showed significant decreases in total cholesterol and triglyceride in the Glipizide group, and a significant decrease in triglyceride in the Tolbutamide group. Some cases showed abnormal values of GOT and GPT in the Glipizide group and abnormal values of red and white blood cells in the Tolbutamide group.
- 一般社団法人 日本糖尿病学会の論文
一般社団法人 日本糖尿病学会 | 論文
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