A study on the relationship between apoptosis-associated factors and clinico-pathological features in tongue squamous cell carcinoma

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概要

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• The aim of this study was to investigate the relation of various apoptosis-associated factors with histological grades and clinical features of tongue squamous cell carcinoma (SCC). The subjects were 35 primary cases of tongue SCC: 25 cases had no recurrent tumor, one case had recurrence and 9 cases died. However, 2 cases of double cancer were included: one who had recurrence and one who died. Hematoxylin eosin (HE)-stained sections were examined to determine histological grades according to the WHO classification. TUNEL and immunohistochemical staining for Fas, Fas-ligand (Fas-L), bcl-x (bcl-xL), Bax, cpp32, Rb, p53 and ki-67 were performed, and their immunoreactivities were evaluated. p53-positive cases were screened for p53 mutation using PCRSSCP. The results were as follows:<BR>1. Fas expression in histological grade II cases was lower (p = 0.093) than that in grade I cases. The expression was also decreased in 6 cases who died of tumor within 2 years and 2 cases who had double cancer as compared with other cases (p<0.05).<BR>. The labeling index for p53 was significantly higher in 6 cases who died of tumor within 2 years and2 cases who had double cancer as compared to other cases (P<0.05).<BR>3. Labeling indexes for TUNEL, Rb protein and ki-67 and expression of bcl-xL, bak, Fas-L and cpp 32 had no significant relation with grades of tumor differentiation and prognosis.<BR>4. p 53 mutation was observed in exon 6, 7 and 8in 4 cases of 18 p53-positive cases. The number of cases was insufficient to clarify the relation of p53 mutation with histological grades and prognosis.<BR>These results suggest that decline of Fas expression and increase of p53 expression indicate progression of histological grade and poor prognosis of tongue SCC.

• 特定非営利活動法人 日本口腔科学会の論文

特定非営利活動法人 日本口腔科学会 | 論文

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