Clinical Significance of Persistent Infection of Hepatitis Viruses in Patients with Oral Cancer

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The seroprevalence of HBs antigen (HBs Ag), anti-HCV antibody (anti-HCV), and transfusionassociated TT virus (TTV) DNA was studied in 80 patients with oral cancer. Control screening was also conducted for 28 other dental diseases, 47 hepatoellular carcinoma (HCC), and 181 subjects. HBs Ag, and-HCV and TTV DNA were detected in 1.3%, 7.5% and 50.0% of oral cancer patients, and the superinfection between HCV and TTV was found in 10%. As for 28 other dental diseases, HBs Ag, anti-HCV, and TTV DNA were detected in 3.6%, 3.6%, and 10.7%, respectively, and in 6.4%, 72.3%, and 59.6% of 47 HCC. Among 72 oral cancer patients confirming the existence of the blood transfusion, TTV DNA was detected in 57.1% of transfusion patients and in 37.8% of nontransfusion patients. There was no significant difference between the two groups. The liver function test values showed also no significant differences between the two groups with and without TTV DNA. On the contrary, the positive rate of HBs Ag, and-HCV, and TTV DNA in control subjects were 1.1%, 1.7%, and 18.8%, respectively. In oral cancer patients, TTV infection was significantly higher than other dental diseases and control subjects (p<0.05). The results suggested there is a possibility in which the hepatitis virus, including HCV and TTV, plays some important roles for the pathogenesis of oral cancer.
特定非営利活動法人日本口腔科学会の論文