Recurrent Behavior after Primary Infection with Herpes Simplex Virus Type 1. Report of 2 Cases.

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Recurrent behavior after primary infection with herpes simplex virus type 1 (HSV-1) in two patients was reported. The patients were 11 and 24-year-old females. The excretion of HSV-1 into saliva, the presence of recurrent herpetic lesion and the change of neutralizing, IgM and IgG antibodies to HSV-1 were observed for 6 months in the child and 12 months in the adult. Saliva was collected in both cases everyday, and serum was obtained every month. In the child, HSV-1 was isolated assymptomatically from saliva two times, 2 and 5 months after onset. The neutralizing antibodies attained a maximum level after 2 months. IgM and IgG antibodies showed a peak after 1 month and 2 months, respectively, which dropped to relatively low levels thereafter. In the adult, HSV-1 was isolated from saliva five times symptomatically and two times assymptomatically. The neutralizing antibodies attained a maximum level after 6 months. IgM and IgG antibodies showed a peak after 2 and 4 months, respectively. These levels rose at the time of appearance of a herpetic lesion. These results suggested that recurrent behavior of a child is different from that of an adult.
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