Effects of Sex Steroids on Rat Oral Mucosa.

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Abstract: Oral discomfort is known as a common manifestation in postmenopausal women, and a close relationship is suggested between oral discomfort and the levels of sex steroids. In this study, ovariectomised rats were compared to sham-operated rats both histologically and immunohistochemically using anti-PCNA antibody to evaluate the effects of sex steroid on oral mucosa. The results were as follows:<BR>1) In the ovariectomised rats, the thickness of oral mucosa were smaller than that in sham-operated rats, and significant differences were observed in the tip of the tongue.<BR>2) From the results of immunostaining using anti-PCNA antibody, the turnover period was prolonged in ovariectomised rats at the tip of the tongue, which may affect the thickness of oral mucosa.<BR>3) The levels of sex steroids are changed in the climacteric period, which could contribute to the histological change of oral mucosa, as well as the onset of oral discomfort inpostmenopausal women.
特定非営利活動法人日本口腔科学会の論文