Electronmicroscopic- and Immunohistochemical-studies of Human Tongue Squamous Cell Carcinoma.
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概要
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The ultrastructures and expression of transferrin receptor (TfR), which is a potential marker for the proliferation activity, in addition to the histopathological investigation were examined to clarify the degree of malignancy in the tongue squamous cell carcinoma.<BR>Tissue samples used in this study were obtained from the 41 patients with tongue squamous cell carcinoma at biopsy or operation. In addition to the examination of clinical features (T classification), pathological features (WHO classification), electronmicroscopic investigation, and immuno-histochemical investigation with TfR were performed, comparing the 22 non-metastatic cases with the 19 metastatic cases. Further, the localization of TfR was examined by the immunoelectronmicroscopic technique.<BR>In the metastatic cases, numerous microvilli and a small number of desmosomes were found regardless of the width of the intercellular spaces. In the non-metastatic cases with wide intercellular spaces, few microvilli were found, and in the non-metastatic cases with the narrow intercellular spaces, numerous microvilli with a large number of desmosomes were observed. All the tumor tissues reacted strongly with the monoclonal antibody for TfR, but the degree of the reaction varied from case to case. The localization of TfR was recognized in the cell membrane, especially microvilli.<BR>The results suggested that the features of microvilli might indicate the degree of the proliferation activity and the malignancy of the tongue carcinoma.
- 特定非営利活動法人 日本口腔科学会の論文
特定非営利活動法人 日本口腔科学会 | 論文
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