The produce of experimental cleft palate model by drilling in midpalatal suture.

概要

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In order to obtain an experimental model of cleft palate in growing rats, the midpalatal suture of the maxillary palate in 20 day old wistar rats was drilled with a #3 (1.2 mm) round bur and the histological healing process was studied chronologically.<BR>The results are summarized as follows:<BR>1.15 days after drilling, the entire circumference of the hole was covered by oral epithelium. No inflammatory cells were observed in the lamina propria and new bone formation was progressing on the bony edge of the operated field. As a result, the margin of the wound was considered to be healed completely within 15 days after drilling.<BR>2. The body weight of the rats was slightly lower than that of a control group shortly after drilling. No difference was observed between the two groups, however, 20 days after the operation.<BR>3. It is concluded that an experimental model of the cleft palate rats approximating the anatomical condition can be obtained by drilling the midpalatal suture of young rats.
特定非営利活動法人日本口腔科学会の論文