Morphological studies on the rat submandibular gland during postnatal development.

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The postnatal differentiation of the submandibular gland of 0 day to 3 month old rats was studied under the light and electron microscope.<BR>Lipid droplets accumulated in the basal cytoplasm of secretory cells of the terminal tubule at 1 day and 2 days of birth. No lipid droplets were, however, found in the gland at birth. Lipid droplets began to decrease in number from 3 days after birth, and few lipid droplets were seen in the gland of 5 day old rats. Histochemical staining with Sudan III and Nile blue suggested that the lipid droplets are mainly triglyceride.<BR>From the specimens which were serially sectioned and stained with Alcian blue, it was defined that the rat submandibular glands contain mucous cells or mucous acini. At birth, a single mucous cell was found occasionally in some terminal tubules and was observed to become a cluster in later stages. There were several mucous acini in a gland of 4 week and of 3 month old rats, and there were 5 to 20 well developed mucous acini in that of 6 month old rats.<BR>The relative area occupied by a terminal tubule cell per terminal tubule was measured on sections. In rats weaned at 3 weeks after birth, the percentage on 3, 4, 5 and 6 week olds were 45.5%, 15.8%, 4.3% and 1.0% respectively. On the other hand, in rats weaned at 4 weeks after birth, the percentage on 4, 5 and 6 week olds were 41.8%, 13.7%, and 3.4% respectively.
特定非営利活動法人日本口腔科学会の論文