Demonstration of Chlamydophila pneumoniae and Chlamydia Stress Protein, HSP-60 in Heart Muscle Tissue.
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概要
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There has been much attension to the association between <I>Chlamydophila pneumoniae</I> and athrosclerosis since <I>C. pneumoniae</I> was demonstrated in macropharges, and vascular smooth muscle cells of atheroma tissues.<BR>There are few data demonstrating whether <I>C. pneumoniae</I> is present in other tissues than atherosclerotic tissues. We surveyd samples of heart tissue from 10 patients with ischemic heart disease and 10 patiens with other disease by immunohistochemical staining with monoclonal antibodies against <I>C. pneumoniae</I> and <I>Chlamydia</I> stress protein 60 (C. HSP-60). In all, 11 out of 20 (55.0%) samples were positive for <I>C. pneumoniae</I> and 7 out of 20 (35.0%) for <I>Chlamydia</I> HSP-60. In patients with ischemic heart disease, positive rates were found significantly higher, that is, 9 out of 10 (90.0%) were positive for <I>C. pneumoniae</I> and 6 out of 10 (60.0%) for <I>Chlamydia</I> HSP-60. These results indicate the common presence of <I>C. pneumoniae</I> in heart tissue in older patients with ischemic heart diseases.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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