Increased Production of Interleukin-10 by Human Blood Monocytes Stimulated with Mycobacterium avium-intracellulare complex.
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概要
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Macrophages produce various cytokines in response to mycobacteria, including interleukin 10 (IL-10) and tumor necrosis factor alpha (TNF-α). IL-10 has been shown to down-regulate numerous macrophage functions, including microbicidal activity against intracellular bacteria and parasites. IL-10 also inhibits interferon-gamma (IFN-γ) production and antigen-specific proliferation of Thl cells mediating immunologic resistance to mycobacterial infection. In contrast, TNF-α activates macrophages and may augment their mycobactericidal activity. In this study, peripheral blood mononuclear cells (PBMC) or blood monocytes obtained from healthy tuberculin reactors were stimulated in vitro with heat-killed <I>Mycobacterium tuberculosis</I> or heat-killed <I>M. avium-intracellulare</I> complex (MAC) to produce IL-10 and TNF-α. We studied a total of 26 clinical isolates of <I>M. tuberculosis</I> and 28 isolates of MAC. MAC-stimulated PBMC and monocytes released significantly larger amounts of IL-10 than those cells stimulated with <I>M. tuberculosis</I>. However, there was no difference in induction of TNF-α production between MAC and <I>M. tuberculosis</I>. When TNF-α activity was neutralized by the addition of anti-TNF-α mAb in culture, MAC still induced more IL-10 secretion than did <I>M. tuberculosis</I>. These findings suggest that increased production of IL-10 by MAC-stimulated monocytes may play a role in the intractable disease caused by these organisms.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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