Protective Effect of Human Macrophage Colony-Stimulating Factor(hM-CSF) on Fungal Infection. (1). In Vivo Effect of hM-CSF on Systemic Candidiasis and In Vitro Effect of hM-CSF on Macrophages Activities.:<I>In Vivo</I> Effect of hM-CSF on Systemic Candidi
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We studied the protective effect of human macrophage colony-stimulating factor (hM-CSF) on fungal infection due to systemic candidiasis <I>in vivo</I> and the activities of macrophages <I>in vitro</I>, in order to demonstrate the usefulness of M-CSF on fungal infection.<BR>The effect of hM-CSF on systemic candidiasis was examined by using normal and immunosuppressed mice. In addition, the effects of hM-CSF on the activity of reticuloendothelial system (RES) organ and on the phagocytic activity and NBT reduction activity of mouse macrophage were also examined <I>in vitro</I>.<BR>HM-CSF improved the survival rate of systemic candidiasis in both normal and immunosuppressed mice. Combination therapy with hM-CSF and fluconazole showed higher survival rate more than in the therapy with either hM-CSF or fluconazole alone. Furthermore, hM-CSF enhanced the activity of RES organ, phagocytosis by macrophages and NBT reduction by macrophages, significantly.<BR>These results indicate that hM-CSF enhances the phagocytic cactivity and candicidal activity by macrophages <I>in vivo</I>, thereby preventing dissemination of fungal infection.
- The Japanese Association for Infectious Diseasesの論文
The Japanese Association for Infectious Diseases | 論文
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