Study on the Analysis of Measurement of Cardiac Output by an Electrical Impedance Method
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A transthoracic impedance plethysmography with four electrodes was successfully developed by Nyboer et. al. in order to measure cardiac output. However, many questions concerning the principle and the precision and working range in practical use have been discussed.<BR>The main object of this report is to evaluate quantitatively both these questions and the origin of the impedance variations through the expansible tube model and animal experiments. Results obtained from the experiments were as follows : <BR>1) Electrolyte fluid flow in an expansible tube can be measured precisely by the impedance method.<BR>2) The relationship between tube length and hydraulic frequency characteristics was investigated in order to establish the working range of the method.<BR>3) Fourier analysis of the aortic flow curve clearly indicates that the high frequency cut off point of the method is beyond the 5 th harmonic of the curve.<BR>4) A comparison study with simultaneous impedance and electromagnetic flowmetry was carried out on 25 dogs; the correlation coefficient on individual dogs was γ=0.70, and that on a dog whose cardiac output was controlled by the application of chemical agents (adrenalin and vagostigmin) wasγ=0.92.<BR>5) A sinusoidal flow pump, which supplies controlled blood flow into the aorta and pulmonary artery, was constructed to investigate, the origin of the transthoracic impedance variation. It was concluded that the variation was caused mainly by aortic flow rather than pulmonary flow.<BR>6) Based on the above results, it is suggested that the measurement of cardiac output by the method should be useful in clinics so far as relative values of cardiac output are concerned.
- 一般社団法人 日本生体医工学会の論文
一般社団法人 日本生体医工学会 | 論文
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