Nematicidal and annelicidal activities of phenylazophenol derivatives

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Nematicidal and annelicidal activities of 4-phenylazophenol derivatives, which had shown remarkable toxicity against animal parasitic nematodes (Rhabdias bufonis, Ascaris lumbricoides, Anchylostoma canninum) and Eisenia foetida, were evaluated against Panagrellus redivivus and two species of aquatic oligochaetes (Branchiura sowerbyi, Criodrilus bathybates) by applying the immersion test. The most effective compounds against Panagrellus were P-11, 13, and 73, which result from the substitution of Cl, Br or CH3 in the p-position of the benzen ring. Many NO2 substituted derivatives were very effective against Branchiura. In particular, P-10, 62 and 99, which derive from the substitution of NO2 and halogen in the p-position of the benzen ring and the 3, 5-position of the phenol ring, showed a high toxicity. The most effective compound against Criodrilus was P-62. When the toxicity of the azo compounds aginst the four species of nematodes was compared, the effect on Panagrellus was similar to that on Anchylostoma but different from that on Rhabdias. No remarkable difference of toxicity among the three species of oligochates was observed.
日本線虫学会の論文