Generation of Monoclonal Antibodies Against a Novel Coagulant Cancer Antigen 1 (CCA-1) and it's Expression on Human Cancer Cell Lines
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概要
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Two monoclonal antibodies AI18 (IgM) and AI51 (IgG1) were generated against the Factor X activating coagulant serine protease which extracted from LK52 human squamous cell carcinoma cell line. Both antibodies inhibit the activity of LK52 coagulant serine protease, but not of Russel's viper venom. AI18 and AI51 react with human lung and colon cancer cell lines, but not react with mouse cancer cell lines, rabbit cancer cell line or human fibroblast cell lines from lung and colon. From these results, LK52 coagulant serine protease was named as coagulant cancer antigen 1 (CCA-1). This is a first report of a novel CCA-1 expression on various human cancer cell lines. CCA-1 may play a important role in unbalanced haemostasis of cancer patients.
- 一般社団法人 日本血栓止血学会の論文
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