Study of the activation mechanism of dextran sulphate on fibrinolytic activity
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概要
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Studies from many laboratories have indicated that dextran sulphate (DS) enhanced the fibrinolytic system, as shown in shortening of euglobulin lysis time. For the activation mechanisms of DS on fibrinolytic activity, it has been proposed that DS enhanced the fibrinolytic activity induced by contact activation, or accelerated the action of plasminogen activators. In this paper, we investigated the activation mechanisms of DS on fibrinolytic activity in vitro and in vivo system.We discovered that DS, orally administrated into rabbits (ranged 50-300mg/kg), suppressed the plasmin inhibitory activity, as measured by the diameter of lysis area on plasminogen-free fibrin plates. The suppressive action of DS on plasmin inhibitory activity was related to the dosage of DS administrated, and occasionally the fibrinolytic activity of euglobulin was enhanced.Furthermore, 2 groups of 19 subjects, 14 patients with hyperlipemia and 5 healthy volunteers were administrated orally 1, 800mg of DS daily from 4 to 47 weeks. Abnormal high levels of plasmin inhibitory activity in patient peripheral blood were reduced to normal levels in a few weeks after the DS medication, but normal levels of that in healthy subjects were not significantly changed. In vitro system, we could not estimate that DS (ranged 10-500μg/ml) might enhance the action of urokinase, nor that DS might accelerate the fibrinolytic activity induced by contact activation.This result suggested that the activation mechanisms of DS on fibrinolytic activity could depend upon the reduction of plasmin inhibitors.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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