Platelet and BM-1. The inhibition mechanism of BM-1 on aggregation of platelet.:The inhibition mechanism of BM-1 on aggregation of platelet
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In vitro, the effects of BM-1 (extracts from the mackerel) on platelet aggregation induced in platelet rich plasma (PRP) by ADP, collagen, epinephrine and A. A. (arachidonic acid) was inhibited by BM-1. But platelet aggregation by PMA (phorbol 12, 13-myristate acetate) was not inhibited by BM-1.In the platelet suspension, when BM-1 was removed from the medium, inhibition of platelet aggregation by BM-1 was not observed.Cytoplasmic free Ca2+ was measured in human platelets using the intracellularlytrapped fluorescent indicator Fura-2.Thrombin-induced increase in cytoplasmic free Ca2+ was inhibited by BM-1. When BM-1 was removed from the medium, inhibition of the rise in cytoplasmic free Ca2+ was not found.The present findings would suggest that there were unknown factors in BM-1 which inhibited the aggregation of platelet and the rise in cytoplasmic free Ca2+ of platelets.
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