The prediction of intra-aneurysmal thrombus-formation. Especially, measuring FPA, and FDP-E, and In-111 loaded platelets-scintigraphy.:Especially, measuring FPA, and FDP-E, and In-111 loaded platelets-scintigraphy

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We evaluated the examinations to predict intra-aneurysmal thrombus-formation by the estimation of FPA and FDP-E in blood, and scintigraphy by In-111-loaded platelets (platelets scintigraphy) in 11 patients.The FDP-E value was 682.7±761.97ng/ml (Mean±SD), and seems to reflect the quantity of intra-aneurysmal thrombus. Especially, all 4 cases with FDP-E higher than 500ng/ml had massive intra-aneurysmal thrombus by CT scan.The FPA valuue was 33.0±63.25ng/ml (Mean±SD), and seemed to indicate thrombogenicity. All 5 cases with FPA values higher than 5.0ng/ml showed strong radioactivity at the same site of intra-aneurysmal thrombus shown by platelets scientigraphy.Both acute dissecting aneurysm cases showed high FPA values (238ng/ml and 5.9ng/ml), while all 3 chronic cases showed normal FPA values (less than 2.0ng/ml).In the case of acute dissecting aneurysm with FPA value of 23.8ng/ml, platele scintigraphy showed strong radioactivity in the false luemn. Moreover, the false lumen was occluded by thrombus after 6 months later, and FPA decreased to 0.6ng/ml. This case shows that platlet scintigraphy is valuable for the diangosis of the site of active thrombus in aortic aneurysm.These results suggests that it is possible to predict intra-aneurysmal thrombus formation by measuring FPA and FDP-E and In-111 loaded platelet scintigraphy.
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