Plasma prostaglandin I2 regenerating activity in diabetic patients.
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概要
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It has been reported that normal plasma (PPP) stimulates prostacyclin (PGI2) production by aortic endothelial cells. Since PGI2 has potent antiaggregatory and vasodilating activities, this plasma PGI2-regenerating activity could be of etiological and clinical importance in thrombotic disorders. We examined it in diabetic patients by the modified method of Remuzzi et al. PGI2-like activity was assayed by the inhibitory effect on ADP-induced platelet aggregation of citrated plasma which had been incubated with the "exhausted" rat aorta for 1h at 37°C. Control PPP obtained from 27 normal volunteers stimulated the exhausted rat aorta to produce 0.84±0.17 (M±SD)ng/mg aorta/h of PGI2-like activity, while PPP from 20 diabetic patients showed a significantly decreased activity (0.48±0.30) as compared with normal one (p<0.001). Because the reduced PGI2-regenerating activity was improved in 6 of 9 patients during appropriate treatment, this reduced plasma activity appeared to be reversible and related to the degree of diabetic control. Patients with diabetic retinopathy had a significant decrease (p<0.05) in their plasma PGI2-regenerating activity (0.30±0.20, n=10) compared with those without retinopathy (0.66±0.26, n=10). Thus, the decrease in plasma PGI2-regenerating activity of patients with diabetes mellitus may play a pathogenic role in the development of the microvascular and thrombotic complications frequently seen in this disorder.
- 一般社団法人 日本血栓止血学会の論文
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