Changes in fibrinolytic, coagulative and kinin systems in healing of experimental gastric ulcer
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Close relation of an experimental gastric ulcer development to coagulative, fibrinolytic and kinin systems has been widely recognized. In the present study, the fluctuations of coagulative, fibrinolytic and kinin systems in passage of time were compared against the morphological alteration in the ulcer healing process. Male adult beagles were used as experimental animals, and an acute gastric ulcer (UL-II) was produced in each by contact freezing of the branches of gastric arteries on the serosal side in the lower corpus. The tissue plasminogen activator levels in the ulcer region, surrounding embankment and in distant normal regions continually lowered for 24 hours, after which they all recovered to the normal levels. The plasma plasmin inhibitor levels started to be elevated after the passage of 24 hours, but returned to their normal range in 2 weeks. The plasma plasminogen stayed relatively unchanged throughout the process. The coagulation factors V and VIII were low untill the end of the 2nd week, after which they returned to normal. The kinin like peptide activity was low throughout the first week, showed marked release in the 2nd week, and was restored to normal at the end of the 4th week. The histologic view and microangiogram revealed repair and a marked change in fine vessels consisting of variegated and dense hyperplasia in the 2nd week, while the coagulative, fibrinolytic and kinin systems also underwent changes of a similar pattern, which indicates that the former was correlated to the latter.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
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