Changes in blood constituents by pentoxifylline administration

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Close relation of blood viscosity to cerebral thrombosis in the aged has been widely recognized. Recently the medical attension has been paid to the usefulness of pentoxifyllin, which is a xanthine preparation, and elicits the increase of blood flow in sclerotic small arteries by lowering blood viscosity in the treatment of arteriosclerotic disorders. The characteristics of pentoxifylline is suggestive of the effectiveness in the treatment of the symptoms which might be derived from arteriosclerosis of the brain in the aged. The purpose of this study is to observe the effect of pentoxifylline on the blood constituents and to elucidate the relation of the changes in the blood constituents to the improvement of their complaints in the aged.Twenty three aged subjects with mean age of 77.1 received orally 300mg of pentoxifylline a day for 8 weeks. Analysis of blood constituents was carried out before and after the administration. Levels of fibrinogen, α1-antitrypsin, antithrombin III, IgG, IgA, IgM, transferrin and haptoglobin were determined by single radial immunodiffusion method.Changes of blood constituents are shown in Fig. 2. There was significant decrease in the level of hemoglobin, hematocrit, total protein, globulin, fibrinogen and α1-antitrypsin, and elevation in A/G after the administration for 8 weeks. No change was observed in the levels of FDP, α2-macroglobulin and antithrombin III. Remarkable effect was observed in heaviness in the head, headache, coldness in the extremities as shown in Fig. 1. Fig. 3 shows the relation of the changes of blood studies to the improvement of the complaints. There was a significant decrease of hemoglobin in cases with improvement of whole symptoms, heaviness in the head and headache, and no statistically decrease in those without improvement of these symptoms. The significant decrease of hematocrit was found only in the cases with improved whole symptoms. The fibrinogen level decreased significantly even in cases without improvement, however, the reduction in the improved cases was higher compared with that in the unimproved cases.The decreased hematocrit, as shown in a report on pentoxifylline administration, was also demonstrated in this trial, however, the most noticeable finding was the decrease in fibrinogen and globulin levels. Contribution of hematocrit to blood viscosity has been widely recognized. The decrease of hematocrit after administration in our study confirmed further the favorable effect of this preparation on blood viscosity. There are some disputes about the contribution of fibrinogen and globulin to blood viscosity. The decrease in fibrinogen and globulin levels in our study may indicate their important responsibility to the reduction of the visicosity of blood. Change of blood constituents accompanying the improvement of clinical arteriosclerotic symptoms was also noticeable finding in this trial.It is concluded that these results indicate the important significance of blood constituents in blood viscosity in arteriosclerosis of the brain and the usefulness of pentoxifylline.
一般社団法人日本血栓止血学会の論文

一般社団法人日本血栓止血学会 | 論文

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