An Experimental Study about the Mechanism and the Prevention of Postoperative Gastric Stasis Following Pylorus Preserving Pancreatoduodenectomy.
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the mechanism of postoperative gastric stasis following pylorus preserving pancreatoduodenectomy (PpPD) with two experimental models. First, the duodenum transection and re-anastomosis was performed at 1 cm (group I), 2cm (group II) and 4 cm (group III) distal to the pylorus to interrupt the intramural neural pathways in rats, and then gastric emptying was measured with the phenol red method at 2 or 4 weeks after surgery and neuronal nitric oxide synthase (nNOS) containing neurons in the duodenal myenteric plexus were examined immunohistochemically. Second, the pancreatoduodenectomized dogs were divided into two groups of the pylorus preserving (PP) and the pylorus partial resection (PPR) by means of the duodenojejunal reconstruction, and then gasric emptying was measured with the acetaminophen method at 2 and 4 weeks after surgery.<BR>In duodenum transected rats, there were no significant differences between gastric emptying of group III transected distal to the papilla of Vater and normal controls, whereas both of group I and group II transected oral to it showed significantly delayed gastric emptying (<I>p</I><0.05) and the increase of nNOS containing neurons in the distal and the decrease of those in the oral to the anastomosis. In the PpPD dogs, the pylorus preserving group showed significantly delayed gastric emptying compared with the partial resection group or preoperative controls. These results suggest that the decrease in nNOS containing neurons due to the transection oral to the papilla of Vater causes delayed gastric emptying and may be related to postoperative gastric stagnation following pylorus preserving pan-creatoduodenectomy.
- 日本平滑筋学会の論文
日本平滑筋学会 | 論文
- S-11. 直腸癌に対する肛門温存手術後の排便障害と新直腸の運動障害との関連性(大腸疾患術前・後の消化管機能と臨床的意義,シンポジウム2,第50回日本平滑筋学会総会)
- SII-7. 血管における病態シグナリングと遺伝子発現制御機構 (薬物受容体・情報伝達の分子機構と分子治療学)
- 27. FD症例における胃排出能・胃貯留能の特徴 : 造影剤含有カプセル法による評価法の有用性と問題点(一般演題「消化器3」,第48回 日本平滑筋学会総会)
- S-6. Benzoyl-L-Tyrosyl-[l-^C] Alanineを用いた呼気膵外分泌機能検査法と脂肪および窒素の便中排泄量との関連(^C化合物を用いた消化器機能評価法,シンポジウム1,第50回日本平滑筋学会総会)
- S2-5.^C-古稀ガス診断を用いた水害分泌機能検査法(呼気試験の現状と未来,シンポジウム2,第48回 日本平滑筋学会総会)