A Case of Bronchial Asthma Improved by Proton Pump Inhibitor.

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A 87-year old female had hypertension and she used Ca-blocker for about 30 years. She developed wheezing during the last 1 year and was treated with teophlline and anti-allergic drug. Bronchial asthma became worser, despite treatment with aminophylline and hydrocortisone. Subsequently, she had wheezing, heart burn, chest pain and appetite loss. Upper gastrointestinal fiber scopy showed ref lux esophagitis. After treatment with proton pump inhibitor, wheezing was controlled and other symptoms disappeared. Sliding esophageal hernia, severe constipation, round back, therapies with Ca-blocker, aminophylline and hydrocortisone were precipitating factors for gastro-esophageal ref lux disease. Gastro-esophageal ref lux may trigger or exacerbate bronchial asthma. We must have a attention to relationship with bronchial asthma and gastro-esophageal reflux.
社団法人日本消化器内視鏡学会の論文