Comparison between Morphogenesis and Apoptosis on Colorectal Tumor.

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The aim of this study was to investigate whether a disturbance in balance between cellproliferation and apoptosis might underlie colorectal neoplastic development or shape. Atotal of 8 colorectal adenornas and 51 early colorectal carcinomas(9 0f depressed typecancer and 42 of polypoid type cancer)were selected for this study. Apoptotic cells weredetected using the terminal deoxynucleotidyltransferase-mediated dUTP nick-end labelingassay(TUNEL assay). bcl-2, and p53 expression were analyzed using the immunoperoxidase technique. The association between apoptotic rates(Apoptosis labeling index;ALI)and bcl-2 and p53 expression was examined. The results were as follows; 1) ALI were not correlated between depressed type and polypoid type in earXy color-ectal cancer. This result suggests that the shapes of early colorectal cancer are notaffected by apoptotic rates. 2) ALI versus p53 averexpression demonstrated a inversecorrelation. ALI in adenoma had significantly higher khan in early colorectal cancer.Adenomas are affected by p53-dependent apoptosis which occur in normal colorectalepithelium. 3)We detected cytaplasmic bci-2 expression in l of 8 (12.5%)depressed type.This rate was significantly lower than in adenoma and polypaid type.
社団法人日本消化器内視鏡学会の論文