Basic and clinical study of endoscopic injection sclerotherapy.

概要

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For a basic study of endoscopic injection sclerotherapy (EIS) for esophageal varices, a comparative study was conducted in terms of histological changes whereby sclerosing agent for the treatment of esophageal varices was infused into the veins of rabbit ears. The sclerosing agents included are classified in order from the strongest effect on thrombophilia to the least as follows : thrombin (T) > 5% ethanolamine oleate (EO) > 2% sodium tetradecyle sulfate (TSS) ≥ absolute ethanol (AE) > 1 % Aethoxysklerol (AS) > 50% glucose (G). Next, EIS using EO was studied clinically. Among 155 patients who underwent complete infusion with the agent into the varices, 150 cases (96.8%) were recognized of which the bronze varices changed into bronze spot, and the varices subsequently disappeared. Four cases (2.6%) revealed complications of necrosis and shedding of tissue associated with bronze varices and one case of recurrence was recognized from bronze varices. It was considered important to monitor the condition of varices after EIS in order to evaluate the effectiveness of treatment and to determine the prognosis.
社団法人日本消化器内視鏡学会の論文