CLINICAL AND EXPERIMENTAL STUDIES ON DYE SCATTERING METHOD AT LAPAROSCOPIC EXAMINATION

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The scattering dye on the liver surface at laparoscopic examination is very useful for the detection of liver fibrosis. We have used the scattering dye method with Indigo carmin in 500 cases and studied relationship between the condition and severity with histology of biopsied specimen. Also, histologic studies were carried out in areas where the dye pooled by utilizing autopsied livers and dog livers. The scattering dye pooled on the liver surface just over the fibrosis of Glisson capsules. The breadth or depth of pooling dye accorded with the extent of the fibrosis. Generally. as collagen fibers of the liver increase, more scattering dyes are seen on the liver surface. And as lobular distortion becomes severer, more scattering dyes connect each other just like the networks of collagen fibers of the liver. These findings are exactly similar to fine collagen fibers stained in blue by AZAN staining. Dye scattering findings and histologic appearances coincided in 87.6% except for 62 cases which did not coincide due to overreading. We thought that these facts revealed the necessity of dye sattering method for detection of minute changes of liver fibrosis.
社団法人日本消化器内視鏡学会の論文