Antagonistic effects of yohimbine and 4-aminopyridine against xylazine-ketamine anesthesia in cats.

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The effects of yohimbine (YO) and 4-aminopyridine (4-AP) on the anesthesia induced by xylazine and ketamine were studied in cats. Three groups of cats were given intramuscular (IM) injection of a mixture of xylazine (2 mg/kg) and ketamine (15 mg/kg) 10 minutes followed on atropine (0.05 mg/kg) LM. On 15 minutes interval cats, in group 1) (control) were given IM injection of saline solution (0.5 ml/kg) . Cats in group 2) were given a mixture of YO (0.3 mg/kg) and 4-AP (0.5 mg/kg) by intravenous injection. Cats in group 3) were given a mixture of YO (0.3 mg/kg) and 4-AP (0.5 mg/kg) IM.<BR>Mean time to pedal reflex (MPT), mean time to arousal sign (MAT), mean time to head-up (MHT), mean time to walk (MWT) and mean time to normal walk (MNT) after YO and 4-AP injection in group 1) were 55. 0, 85. 8, 94. 8, 112.0 and 216.0 minutes, respectively. In group 2) and group 3), MPT was shortened to 3.4 and 18.4 minutes, MAT was shortened to 5.7 and 27.0 minutes, MHT was shortened to 12.2 and 29.8 minutes, MWT was shortened to 45.2 and 44.8 minutes, and MNT was shortened to 107.8 and 96.4 minutes, respectively, compared with group 1) . MPT, MAT and MHT in group 3) were significantly longer than those in group 2) . But, the differences in MWT and MNT between group 2) and 3) were not significant. In both groups 2) and 3), catalepsy was observed during recovery from anesthesia. Relapses to unconsciousness did not occur.<BR>In both groups 2) and 3), the combination of YO and 4-AP reversed the decrease in heart rates, respiratory rates and body temperature elicited by xylazine and ketamine.<BR>The results indicated that the combination of YO and 4-AP can be clinically used as a safe and effective antagonist of xylazine-ketamine anesthesia in cats.
獣医麻酔外科学会の論文

Antagonistic effects of yohimbine and 4-aminopyridine against xylazine-ketamine anesthesia in cats.

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獣医麻酔外科学会 | 論文

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