A Case of Hereditary Thyroxine-Binding Globulin Excess Complicated by Hyperthyroidism

概要

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A 38-year-old housewife with hereditary thyroxine-binding globulin (TBG) excess complicated by hyperthyroidism was followed up over 16 years. This clinical entity is extremely rare and only 6 cases have been reported in Japan. Hyperthyroidism in this case developed initially as T<SUP>3</SUP> toxicosis and a transient rise in TRAb was observed following recovery of thyroid function after antithyroid therapy. A pedigree survey revealed that her mother had a high level of blood TBG, comparable to that of the patient. It required more than 10 years for complete remission of her hyperthyroidism by antithyroid therapy. It was concluded from this fact that the TBG excess has no beneficial effect on the hyperthyroidism.
昭和大学・昭和医学会の論文