A Case of Chromophobe Renal Cell Carcinoma Coincident with Malignant Gastointestinal Stromal Tumor

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We report a case of chromophobe renal cell carcinoma coincident with a malignant gastric gastrointestinal stromal tumor in a 71-year-old Japanese man. Although the occurrence of two coincidental malignant neoplasms is not rare, there are no documented case reports of chromophobe renal cell carcinoma (RCC) combined with gastric gastrointestinal stromal tumor (GIST) . Histopathologically, this RCC showed characteristic features of the chromophobe subtype, despite being negative for colloid iron staining, which is one of the hallmarks of chromophobe RCC. Immunohistochemical analysis of the GIST revealed that the spindle-shaped neoplastic cells were positive for CD34 and CD 117, but negative for smooth muscle actin and S 100. These results are indicative of an 'uncommitted' subtype of GIST. In addition, we extracted genomic DNA from paraffin-embedded sections of the gastric GIST and sequencing revealed a 6 by in-frame deletion in exon 11 of the c-kit gene, a gene that is frequently mutated in GIST. Although the significance of the coincidence of chromophobe RCC with gastric GIST is currently unknown, it will be interesting to investigate whether the molecular basis of oncogenesis is shared between these neoplasms.
昭和大学・昭和医学会の論文