Apoptosis and Origin of Proliferated Bile Ductules in Fulminant Hepatitis:—Pathologic and Electron Microscopic Examination of Hepatic Tissue—

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Proliferation and subsequent loss of bile ductules is a common pathologic disorder in the course of fulminant hepatitis. A pathologic and electron-microscopic study was undertaken to determine the mechanism of bile ductular proliferation and loss, using seven autopsy cases of fulminant hepatitis with different times of onset. The proliferation in bile ductules was mild at 6 days from onset, but had become more severe by 37 days, and by 75 days from onset ductules were deleted. Electron microscopic findings of proliferated bile ductules resembled those of hepatocytes, but at 75 days they showed bile ductular metaplasia. Apoptotic cells were observed in bile ductules between 26-37 days, but could not be found between 6-10 days or at 75 days after onset. From these findings, the proliferated bile ductules of fulminant hepatitis were found to resemble hepatocytes, and the subsequent loss of bile ductules is due to apoptosis.
昭和大学・昭和医学会の論文