Pancreatic Dysfunction and Imaging Abnormalities in Patients with Inflammatory Bowel Disease

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Background : Although patients with inflammatory bowel disease (IBD) frequently exhibit various extraintestinal manifestations, pancreatic disorder is not generally considered as an extraintestinal complication of IBD. We investigated pancreatic dysfunction and imaging abnormalities in patients with IBD. We estimated serum and urinary pancreatic enzyme levels for evaluation of pancreatic function in 42 patients with IBD, including 29 patients with ulcerative colitis (UC) and 13 patients with Crohn's disease (CD) . In addition, some of the patients were examined by ultrasonography, abdominal computed tomography, and endoscopic retrograde pancreatography (ERP) for evaluation of pancreatic imaging. Elevation of serum or urinary pancreatic enzyme concentrations was observed in 23.8 % of patients, and abnormal pancreatic imaging, in 26.7 %. In 4 patients, the pancreatic enzyme concentrations decreased or normalized during remission of IBD. In one patient initial ERP showed irregularity of the main pancreatic duct, and follow-up ERP indicated normal appearances of the duct after remission of IBD. Our observations suggest that pancreatic dysfunction and imaging abnormalities develop in patients with IBD ; moreover, these may relate to the activity of disease and resolve when colonic inflammation is brought into remission.
昭和大学・昭和医学会の論文