Effects of Long-Term UVA Exposure of Human Skin Fibroblasts on Cell Growth and Extracellular Matrix Formation.
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概要
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Repeated exposures to sunlight cause sagging skin or deep wrinkles. These morphological changes, called photoaging, depend on the characteristics of dermal extracellular matrices (ECM), of which type I collagen is a major component. We studied cell growth and ECM formation of human skin fibroblasts under long-term UVA exposure, Secretion of type I procollagen was almost the same as that of the control, while cell growth and ECM formation were greatly inhibited. Reactive oxygen scavengers did not affect this inhibition. The effect of UVA was reproduced when the cells were cultured in UVA-irradiated medium, even though they were not exposed directly to UVA. The growth arrest was not seen when fresh fetal bovine serum was added to the UVA-irradiated medium. These results suggest that the inhibition of cell growth and ECM formation induced by long-term UVA exposure is due to denaturation of growth factors and/or chemokinetic factors rather than to direct cytotoxicity of reactive oxygen.
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