Development of Anti Aging component as a Cosmetic Ingredient. Effect of Hamamelitannin as the Active Oxygen Scavenger.:Effect of Hamamelitannin as the Active Oxygen Scavenger

概要

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The major role of cosmetic in the 21st century wil be in anti-aging. Many mechanisums of aging have been reported. The effect of the active oxygens in aging have been noted. The active oxygens generated by UV irradiation and other stimulations in the body, attack various organs and components. If the active oxygens attack the DNA directly, the DNA is injured, and an error in gene transmission arises. When active oxygens attack the cell membrane, lipids in the membrane are peroxidated. Peroxidation of the membrane is resposible for errors in the various membranes mediating biological reactions. Consequently, it may be presumed that aging is thus caused. Therefore, strong active oxygen scavengers are required for anti-aging. The active oxygen source in a body is superoxide anion. We researched the anti-aging ingredient in plants by using the superoxiae disumutase-like activity (SOD-like activity) as an indicator. It was found that Hamamelitannin in Hamamelis virginiana L. had just such an effect. The effect of Hamamelitannin as the ingredient for anti-aging was evaluated by using in vitro and in vivo methods.
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