Lipid Peroxidation on a Human Skin Surface.
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概要
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The peroxidation of human skin surface lipids was investigated by a CL-HPLC (chemiluminescence-high performance liquid chromatography) system. Squalene mono-hydroperoxide was produced at the forehead and the scalp as well as in the dandruff under daily life conditions in most of the cases. Therefore it was considered that squalene was the first target lipid on a human skin surface by an oxidative stress. In order to confirm the effect of squalene monohydroperoxide on proliferation of cultured cells and TESTSKINTM (Living Skin Equivalent), an authentic squalene mono-hydroperoxide was prepared by a dye-sensitized photooxidation and its chemical structure was identified by 1H-NMR, 13C-NMR and FAB-MS. Detection limit of squalene mono-hydroperoxide in CL-HPLC system was as little as 1 pmol. We also found that cosmetics containing antioxidants had a preventive effect against the lipid peroxidation on a Human Skin Surface.
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