A case of primary non-Hodgkin lymphoma of the uterine cervix.

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A rare case of primary non-Hogdkin's lymphoma of the uterine cervix is reported. An 86-year-old woman who had given birth eight times was examined due to vaginal bleeding. Results of physical examination showed uterine cervical enlargement with parametrium involvement. Cervical and endometrial cytology were negative. Histological study of the cervical biopsy showed diffuse proliferation of medium-sized lymphoid cells. Immunohistochemical studies showed that the lymphoid cells were positive for L-26 and negative for UCHL1, indicating a diagnosis of B-cell lymphoma, diffuse medium-sized type (LSG classification). Thoracic-abdominal-pelvic computed tomography, magnetic resonance imaging (MRI) and Ga-scintigraphy demonstrated that the clinical staging was IIE, using Ann Arbor classification. After three courses of chemotherapy (modified CHOP), MRI showed an reducted uterus, indicating that the cervical lymphoma responded to the chemotherapy. Two further courses of the chemotherapy were then administered. Ga-scintigraphy showed no abnormal uptakes and cervical biopsy showed no evidence of lymphoma. Clinical remission was achieved. Approximately 8 months have passed since the primary treatment was initiated. No evidence of recurrent lymphoma has been observed. [Adv Obstet Gynecol 51 (6); 573578, 1999 (H.11.11)]
近畿産科婦人科学会の論文