Statistical analysis of non-responders to hormone replacement therapy.

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A retrospective study was conducted to find out why among women who received hormone replacement therapy (HRT) at a dose of CEE 0.625mg dialy (207 women for 1 year or more, 104 women for 2 years or more), some of them did not respond to HRT, and to determine the percentage of non-responders to HRT based on lumbar bone mineral density (LBMD) measure, using the DXA method (DPX-L). Non-responders were defined as those women in whom bone loss was higher than the CV of the DXA equipment (0.82 %). The percentage of non-responders was 28.0 % after lyear, and 13.5 % after 2 years. As for the effect of concomitant use of 2.5mg MPA, both the rate of LBMD increase and percentage of responders after 1 year were slightly higher than those observed in the group taking CEE alone, but there was no difference after 2 years. It was observed that the proportion of non-responders was small in the patients with higher age, lower levels of LBMD and higher levels of serum ALP at the start of HRT administration. [Adv Obstet Gynecol 51 (4); 325<SUP>-</SUP> 332, 1999 (H11.7)]
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