A case of primary malignant melanoma of the uterine cervix.
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We encountered an extremely rare case of primary malignant melanoma of the cervix. A 72year-old female with multigravidity (twice) and multiparity (twice) consulted our hospital for genital bleeding. In the vaginal portion of the uterus, phyma with partial black pigmentation was noted. Cervical scraping smear revealed atypical cells with naked nuclei or omnipresent nuclei, marked increases in chromatin and little intercellular binding. The cytoplasm included brown granules. Clinical stage of the patient was classified as cervical cancer stage II b. Abdominal radical hysterectomy with bilateral salping000phorectomy and radiotherapy were performed. Histopathology revealed round tumor cells with polymorphism. In these cells, large nucleoli, intranuclear vacuoles, nuclear division and brown melanin granules with in the cytoplasm were detected. On immunohistochemistry, tumor cells were positive for HMB-45 and S-100 proteins. Electron microscopy revealed melanosomes in the cytoplasm. Sixth months postoperatively, she died because her disease continued to progress rapidly. [Adv Obstet Gynecol 49 (5); 563-567, 1997 (H9.9)]
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