A large dose of methotrexate and rescue by citrovorum for multiple metastasis of gestational choriocarcinoma.

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We treated a 48-year-old woman with multiple metastasis of gestational choriocarcinoma by the use of large dose of methotrexate (MTX) and the rescue by citrovorum factors. The metastasis was extended to lung and liver after the resection of uterine tumor and brain tumor. Dose of MTX (®Methotrexate Inj) was proceeded at 20-100mg per kg of the patients body weigh with the intravenous drip infusion. After its drip infusion, the damage of normal cells was rescued by citrovorum factors (®Leucovorin Inj) under monitoring MTX concentration in serum. The chemotherapy was beyond 5 months (5/23/82-10/12/82) and total doses of MTX was reached to 21, 600mg.As the result of chemotherapy, the size and the number of hepatic tumor was remarkably reduced. However, pulmonary tumor was uneffective for this therapy and its size was increased during the therapy. Side effects which resulted in the therapy, did not almost appear and the patient was in good condition during the course.Clinical course for the patient was presented here.
近畿産科婦人科学会の論文