Ovarian Mutinous Tumors with Hormonal Activity:—Endocrinological and Histological Studies on Two Cases—

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It has been indicated that certain kinds of non-functioning ovarian tumors show hormonal activity. Two postmenopausal cases, (75 and 71 year-old) who had clinical signs of hyperestrinism, were subjected to the present investigation for the origin of steroid production using hormonal and enzyme-histochemical methods.Serial determinations of plasma levels of estradiol, androstenedione, progesterone, 17α-hydroxyprogesterone, 20α-dihydroprogesterone, LH, and FSH throughout the pre- and post-operative periods were performed. The pre-operative values of all steroids were higher than those of healthy normalcases in the corresponding age. Conversely, LH and FSH levels were lower. Plasma levels of these steroids were decreased and those of LH and FSH elevated significantly in the post-operative periods.Histological examinations revealed left ovarian mucinous adenocarcinoma in one case and left ovarian mucinous adenoma combined with right ovarian serous cystadenoma in another case.3β-hydroxysteroid dehydrogenase and glucose-6-phosphate dehydrogenase activities were demonstrated histochemically in the ovarian stroma of both cases.It is concluded that the steroid hormone production sites of two postmenopausal cases who had hyperestrinism were the stromal regions of mucinous adenocarcinoma and serous cystadenoma of ovaries.
近畿産科婦人科学会の論文