A Study of Uteroplacental Blood Flow and Uteroplacental Shunt in Normal and Abnormal Pregnant Rats
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In an attempt to clarify the uteroplacental blood flow (UPBF) and its regulation system in normal and abnormal pregnancies, we studied UPBF in SD strain rats by using the double tracer microspheres method free of anesthesia and restraint, and we proposed the significance of "shunt flow" in myometrium which was considered to be a regulator in UPBF.Pregnancy with hypertension was produced by intramuscular injection of methylprednisolone (20 mg/rat). Spontaneous hypertensive rats (SHR) were also used. Prolonged pregnancy was produced by consecutive intramuscular injection of progesterone (5mg/rat) from the 18th day of gestation. Pregnancy with diabetes mellitus (DM) was produced by single intravenous injection of streptozotocin(65 mg/kg) at the 11th day. The blood pressure in normal and abnormal rats was measured by programmed electrosphygmomanometer PE-300 (Narco Bio-System Inc. ).The UPBF, only 0.5% in nonpregnant rats, tended to increase with pregnant days. In normal pregnancy the observed rate of UPBF was 11%(peak) on the 18th and 10% on the 20th day. The UPBF in the pregnancy with MP-induced hypertension was 5.9%, the shunt rate was 0%, and fetal mortality rate increased on the 20th day of gestation. In the pregnancy of SHR, the UPBF was 8.9%, its shunt rate was 20%, and fetal mortality rate was lower than that of MP-hypertensive group. These results indicated the reason why the SHR could continue to survive as a strain. The UPBF in DM pregnancy was only 2.7%, its shunt rate was 3.4%, and fetal mortality rate was very high (30%). The UPBF in the prolonged pregnancy group showed a value of 6.6% and its shunt rate was 1.5% on the 23rd day. The blood pressure in normal rats did not change remarkably, but the blood pressure in SHR tended to decrease significantly with pregnancy.The microangiographic study revealed the existence of the shunt system in the uteroplacental circulation system.In conclusion, we emphasize the importance of the "shunt flow" as a regulator of the UPBF and fetal development.
- 近畿産科婦人科学会の論文
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