:-Carrageenan and dextran sulfate-on mesangial handling of colloidal carbon in mice
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In order to evaluate the effect of RES blockers on the clearing function of mesangium, suspension of colloidal carbon was injected intravenously to female ICR mice, which were divided into three groups according to the previously administered RES blockers. The group I received carbon injections alone, while group II and III, prior to carbon injections, were treated with injections of carrageenan and dextran sulfate respectively. Following carbon injections, the disappearance rate of carbon from the circulation, as well as chro-nological changes in intraglomerular localizations of carbon particles, was estimated in all three groups. Despite a significant delay in disappearance of intravascular carbon in both groups treated with the RES blockers (group II and III), the mesangial depositions of carbon particles in these groups were reduced in comparison with those in control animals (group I). Observations by electron microscopy revealed a marked increase of carbon-phagocytizing mononuclear cells in glomeruli two days after carbon injections, particularly in animals treated with dextran sulfate (group III). Such mononuclear cells were also found in peripheral blood samples, but with much less frequency than those in glomeruli. Therefore, it seems likely that peak amount of intraglomerular carbon particles, obtained two days following the injections in animals of group III, may reflect mobilized mononuclear phagocytes, rather than carbon-phagocytizing mesangial cells per se. The above findings indicate that RES blockers may have suppressed the mesangial uptake of carbon particles and that infiltrating mononuclear cells in glomeruli may contribute to salvaging of foreign substances. It is also suggested that dextran sulfate may have activated such a salvaging function of mononuclear cells.
- 社団法人 日本腎臓学会の論文
社団法人 日本腎臓学会 | 論文
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