Evaluation of Glutathione-S-transferase (GST)-.PI. as a Tumor Marker in Patients with Oral Cancer.
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Circulating Glutathione-S-transferase-π (GST-π) has been recently known to serve a newtumor marker for diagnosis of various malignant diseases. However, the application of GST-π to patients with oral cancer has not yet beeninve-stigated. In the present study, plasma GST-π was measured with the sandwich enzyme-immunoassay (EIA) system in 44 oral squamous cell carcinomas and 49 healthy subjects. Evaluation for GST-π was also compared with that for serum SCC, a known tumor marker of oral cancer. The results were as follows;1. Plasma GST-π levels in patients with oral cancer and healthy subjects were 59.0±18.6ng/ml and 18.2±6.7ng/ml, respectively (p<0.001).2. Incidence of elevated plasma GST-π for primary oral cancer was 75.0% (24/32), while that for serum SCC was only 31.3% (10/32), indicating that GST-π is far more useful than SCC as a tumor marker for oral cancer.3. Plasma GST-π levels tend to increase in patients with advanced cancer (Stage III and IV) as compared to those with Stage I or II, reflecting the tumor burden.4. Seven of 12 patients (58.3%) in the group of responders to chemotherapy, plasma GST-π level returned to normal level after chemotherapy.5. In patients with no evidence of recurrence, plasma GST-π level returned to normal level after operation. On the other hand, in patients with re-increased GST-π after operation, subsequently recurrences were found.Thus, GST-π is considered to be a reliable and useful marker for oral cancer.
- 日本頭頸部癌学会の論文
日本頭頸部癌学会 | 論文
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