The Effects of Radiation on the cytotoxicity for NK and LAK Activity and the Proliferative Response to IL-2 of the Lymphokine-Activated Killer (LAK) Cells.
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The therapeutic effects of the combination radiotherapy and adoptive immunotherapy with lymphokine-activated killer cells (LAK) generated by incubation in anti- CD3 monoclonal antibody and interleukin-2 (IL-2), plus IL-2 in patients with head and neck tumors, are paticularly interesting.Therefore, 1) The in vivo distribution and duration of accumulation in tumor tissue, of adaptively transferred 99mTc-HMPAO-labeled LAK cells and 2) the effects of radiation on the cytotoxic activity (NK and LAK) and proliferative response to IL-2 of LAK cells, after irradiation at doses ranging from 1.25 to 20Gy. in vitro, were investigated.Clear tumor localization was seen on nucler scan series, and significant radioactivity was still retained in tumor site for more than 24 hours, after the infusion of 99mTc-labeled LAK cells by intra-arterial infusion in patients. The cytotoxic activity of LAK cells for NK and LAK targets, was not suppressed with any doses of irradiation, however, the proliferative response to IL-2 was suppressed with irradiation dose at 1.25Gy. This results suggests that proliferation and expansion of infused LAK cells are supressed in vivo by the irradiation of therapeutic dose. Taking together these results, radiotherapy should be performed to prevent the suppression of proliferation and expansion of LAK cells accumulating in tumor tissue site, by repetitive administraion of IL- 2, to obtain the utmost effects of combination radiotherapy and adoptive immunotherapy with LAK and IL-2.
- 日本頭頸部癌学会の論文
日本頭頸部癌学会 | 論文
- 口腔白板症に対する緑茶カテキンの治療効果に関する臨床的検討
- SUPERSELECTIVE ARTERIAL INFUSION AND CONCOMITANT RADIOTHERAPY FOR ADVANCED HEAD AND NECK CANCER
- MICROVASCULAR SURGERY IN HEAD AND NECK SURGERY
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