Histopathological study of leukoplakia of the tongue

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Fifty-six cases of leukoplakia of the lateral border of the tongue were examined histopathologically.Of 56 cases of leukoplakia, 22 cases (39.3%) showed epithelial dysplasia.The outline of rete process could be classified into the following three types; flattened type, elongating type and drop-shaped type. Epithelial dysplasia was rarely observed in the flattened type. However, 30% of elongating types and 92.9% of drop-shaped types revealed epithelial dysplasia.In addition, the thickness of epithelium in leukoplakia were also examined in relation to epithelial dysplasia. The atrophic epithelium showed epithelial dysplasia more frequently than in the thickened epithelium.
日本頭頸部癌学会の論文